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An Invitation to Cancer Researchers

A blog of questions and problems posted for the Physics and Cancer community.

Cancer Researchers Need… is a blog where questions and problems that cancer researchers come across can be posted for the physics community to address.

An analogy between the evolution of drug resistance in bacterial communities and malignant tissues.

Lambert G, Estévez-Salmeron L, Oh S, Liao D, Emerson BM, Tlsty TD, Austin RH.

Nat Rev Cancer. 2011 May;11(5):375-82.

Source

Department of Physics, Princeton University, Princeton, NJ 08544, USA.

Abstract

Cancer cells rapidly evolve drug resistance through somatic evolution and, in order to continue growth in the metastatic phase, violate the organism-wide consensus of regulated growth and beneficial communal interactions. We suggest that there is a fundamental mechanistic connection between the rapid evolution of resistance to chemotherapy in cellular communities within malignant tissues and the rapid evolution of antibiotic resistance inbacterial communities. We propose that this evolution is the result of a programmed and collective stress response performed by interacting cells, and that, given this fundamental connection, studying bacterial communities can provide deeper insights into the dynamics of adaptation and theevolution of cells within tumours.

PMID:

21508974

[PubMed – indexed for MEDLINE]

Link to Full Paper

Links

Physics of Cancer Metastasis, NSF workshop held in November 2010.

Office of Physical Sciences Oncology, National Cancer Institute,

Princeton Physical Sciences Oncology Center, Princeton University,

Center for the Convergence of Physical Science and Cancer Biology, Arizona State University.

Physics of Living Systems, Science Across Virtual Institutes, University of California, San Diego.

Physics and Mathematics of Cancer, University of California, Santa Barbara, The Kavli Institute for Theoretical Physics.

Focus on the Physics of Cancer, New Journal of Physics.

Welcome

We are pleased to launch the Physics and Cancer website.

We are pleased to launch the Physics and Cancer website in hopes that it will become a useful resource in the advancement of the contribution of physics to cancer research.

Eshel Ben Jacob, University of Tel Aviv

Krastan Blagoev, National Science Foundation

Herb Levine, Rice University